Eaav Madrid 2011

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Niclosamide Powder

The chemical substance niclosamide powder has the formula C13H8Cl2N2O4. It has a cream tint and belongs to the salicylanilide class. It is a USP and EMA standard in the pharmaceutical business. HPLC is used to determine the purity of the product. The supplement is also available in pill form. Niclosamide is not dangerous and is incompatible with powerful oxidizing agents.

Niclosamide powder dissolves in dimethyl sulfoxide but not in water. At 20 °C and 1.013 hPa, it has a relative density of 1,615 g/cm3. Strong oxidizing agents are incompatible with this product.

Niclosamide is not dangerous and is incompatible with powerful oxidizing agents.

In humans, niclosamide has been used as an anticancer medication. Niclosamide has been demonstrated to be beneficial in decreasing fibrosis in chronic liver disease patients (cirrhosis and others). Because it does not produce myelosuppression, niclosamide has an advantage over the other medicine that has been shown to be effective for cirrhosis fibrosis therapy. Because of its non-myelosuppressive action, it is also beneficial for treating solid tumors, particularly when combined with radiation treatment. Niclosamide has been demonstrated to be useful in avoiding nephritis in interstitial cystitis patients. 

In the pharmaceutical sector, niclosamide is used as a standard to determine the purity of the product. High Performance Liquid Chromatography is used to assess the purity and identification of the product (HPLC). Other substances such as sildenafil citrate, sildenafil, phenazopyridine hydrochloride, and others are also analyzed using this purification process. This chemical should first be dissolved in 2M HCl for roughly 3 hours before being used to assess purity. After that, the solution should be left alone until crystals form. The resultant crystals should be dissolved in 10% HCl for about 2 hours. Solid contaminants in the solution should be filtered away. The resultant solution should then be concentrated in a rotary evaporator until it is one-third of its original volume. The completed sample is now ready for HPLC analysis. The niclosamide powder examined in HPLC should have a retention time of around 11 minutes, whereas impurity chemicals have retention durations that are greater.

Impurity discrimination may be accomplished using software or by testing the sample in an HPLC instrument. There are various approaches that may be used to do this assignment. The most often used way is to use a high performance liquid chromatography (HPLC) instrument. A chromatograph may be used to separate molecules based on their retention periods and detect contaminants in a sample. Companies planning to produce sildenafil citrate, sildenafil, and phenazopyridine hydrochloride should adopt this technology.

Another option is to use a paper chromatograph. This is a form of chromatography that separates a mixture into various components by using a large number of paper filters. In this technique, two kinds of filters are employed. The first is supercritical fluid (SFC) extraction, while the second is solid phase extraction (SPE). The SFC has the benefit of removing unsaturated contaminants with short water retention time and of separating colors contained in sildenafil citrate, sildenafil, and phenazopyridine hydrochloride. The SPE has a lower pressure and can separate chemicals with a long water retention period.

Another way of purifying and testing is to use paper chromatography. This method may also be used to evaluate powdered substances such as sildenafil, sildenafil citrate, and phenazopyridine hydrochloride. Because it may harm the compounds in the sample being examined, di-isopropyl nitrite is not advised for use in this procedure.

Niclosamide powder is a transparent substance that ranges in color from white to cream. When seen using an optical microscope, it produces an acidic odor.

It dissolves in dimethyl sulfoxide but not in water. The powder may be used to determine the quantity of the product. For roughly 3 hours, dissolve the powder sample in 2M HCl.

Following this time, the liquid component of the solution will separate and solidify on the bottom of a cup, vial, or beaker.

This solid mass is known as niclosamide, and it may be readily extracted from the solution using filter paper or a filter funnel.

Niclosamide capsules (CAS No. 50-65-7) are a salicylanilide derivative medication. They have a cream tint and the chemical composition C13H8Cl2N2O4. Tapeworm infestations are treated with niclosamide pills. They come in 500mg pill form. Niclosamide capsules should be kept at room temperature in their original package.

Niclosamide pills are administered orally. The suggested dose for adults is 500mg twice day. The suggested dose for youngsters is 25-50mg/kg twice a day. Niclosamide pills must be consumed with meals.

Nausea, vomiting, diarrhea, and stomach discomfort are common adverse effects of niclosamide capsules. Contact your doctor if you suffer any of these negative effects. Niclosamide capsules are not recommended for those who are allergic to the medicine. In individuals with liver illness, niclosamide capsules should be taken with care.

Before using niclosamide capsules, consult your doctor if you are pregnant or nursing. If you have any other medical issues, see your doctor before using niclosamide capsules. Other drugs may interact with niclosamide capsules. Inform your doctor about all of your prescriptions, including over-the-counter medications, vitamins, and herbal supplements. Prescription and over-the-counter medications, vitamins, and herbal supplements are all included.

When taken orally, niclosamide capsules are physiologically active. According to research, niclosamide capsules impede microtubule assembly inside the cell. Nicosamide capsules prevent the creation of new tubulin molecules, which are required for cell division, by blocking microtubule assembly. Nicosamide capsules reduce the amount of tapeworms that may infect a human host by slowing cell division.

Niclosamide capsules contain the medication niclosamide. The medication belongs to the salicylanilides family of medications. Salicylanilides are quinoline compounds with an aromatic ring containing a nitrogen and two methyl groups joined by an ethylene double bond. They likewise have an amino group at R1 and two alkyl groups at the same carbon atoms as the amino group, R4 and R5.

NICLOSAMIDE CAPSULE TECHNICAL DETAILS

Niclosamide capsules (chemical formula C13H8CI2N2O4) is a salicylanilide derivative. It is cream in hue.

5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide is a synonym.

C13H8CI2N2O4 is the formula.

327.12 g/mol molecular weight

4322 is the ChemSpider ID.

1448; ChEMBL ID

P02DA01 (WHO) ATC code

CID PubChem: 4477;

The average mass is 327.120 Da.

325.986115 Da monoisotopic mass

216-230 °C melting points

Solubility: 1 mg/mL DMSO; 1 mg/mL water

Adisant LTD performed an HPLC analysis using a Thermo UltiMate 3000 HPLC System.

Niclosamide capsules should be kept at room temperature in their original package. The melting point fluctuates between 216 and 230 °C.

There are a few methods for determining the purity of niclosamide. Thin layer chromatography is a popular technique (TLC). TLC is a process that involves applying a sample on a plate that has been coated with a thin layer of adsorbent material. The plate is subsequently put in a solvent-containing development chamber. The sample will be carried up the plate by the solvent as it advances up the plate. Based on its solubility in the solvent, the sample will then divide into various components. When the plate is taken from the chamber, the various components emerge as distinct spots on the plate. The sample's purity is then measured by comparing the number of dots on the plate to a recognized standard.

High performance liquid chromatography is another approach for determining the purity of niclosamide (HPLC). TLC and HPLC are comparable, except the sample is introduced into the system under high pressure. This permits the material to be split into its constituents considerably quicker than TLC. The sample's purity may then be assessed by comparing the peak regions of the various components to a recognized standard.

Niclosamide capsules are a salicylanilides type of medication derivative. Niclosamide capsules should be kept at room temperature in their original package. Niclosamide pills must be consumed with meals. Nausea, vomiting, diarrhea, and stomach discomfort are common adverse effects. Contact your doctor if you suffer any of these negative effects.

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