Another way of purifying and testing is to use paper chromatography. This method may also be used to evaluate powdered substances such as sildenafil, sildenafil citrate, and phenazopyridine hydrochloride. Because it may harm the compounds in the sample being examined, di-isopropyl nitrite is not advised for use in this procedure.
Niclosamide powder is a transparent substance that ranges in color from white to cream. When seen using an optical microscope, it produces an acidic odor.
It dissolves in dimethyl sulfoxide but not in water. The powder may be used to determine the quantity of the product. For roughly 3 hours, dissolve the powder sample in 2M HCl.
Following this time, the liquid component of the solution will separate and solidify on the bottom of a cup, vial, or beaker.
Niclosamide capsules (CAS No. 50-65-7) are a salicylanilide derivative medication. They have a cream tint and the chemical composition C13H8Cl2N2O4. Tapeworm infestations are treated with niclosamide pills. They come in 500mg pill form. Niclosamide capsules should be kept at room temperature in their original package.
Niclosamide pills are administered orally. The suggested dose for adults is 500mg twice day. The suggested dose for youngsters is 25-50mg/kg twice a day. Niclosamide pills must be consumed with meals.
Nausea, vomiting, diarrhea, and stomach discomfort are common adverse effects of niclosamide capsules. Contact your doctor if you suffer any of these negative effects. Niclosamide capsules are not recommended for those who are allergic to the medicine. In individuals with liver illness, niclosamide capsules should be taken with care.
Before using niclosamide capsules, consult your doctor if you are pregnant or nursing. If you have any other medical issues, see your doctor before using niclosamide capsules. Other drugs may interact with niclosamide capsules. Inform your doctor about all of your prescriptions, including over-the-counter medications, vitamins, and herbal supplements. Prescription and over-the-counter medications, vitamins, and herbal supplements are all included.
When taken orally, niclosamide capsules are physiologically active. According to research, niclosamide capsules impede microtubule assembly inside the cell. Nicosamide capsules prevent the creation of new tubulin molecules, which are required for cell division, by blocking microtubule assembly. Nicosamide capsules reduce the amount of tapeworms that may infect a human host by slowing cell division.
Niclosamide capsules contain the medication niclosamide. The medication belongs to the salicylanilides family of medications. Salicylanilides are quinoline compounds with an aromatic ring containing a nitrogen and two methyl groups joined by an ethylene double bond. They likewise have an amino group at R1 and two alkyl groups at the same carbon atoms as the amino group, R4 and R5.
NICLOSAMIDE CAPSULE TECHNICAL DETAILS
Niclosamide capsules (chemical formula C13H8CI2N2O4) is a salicylanilide derivative. It is cream in hue.
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide is a synonym.
C13H8CI2N2O4 is the formula.
327.12 g/mol molecular weight
4322 is the ChemSpider ID.
1448; ChEMBL ID
P02DA01 (WHO) ATC code
CID PubChem: 4477;
The average mass is 327.120 Da.
325.986115 Da monoisotopic mass
216-230 °C melting points
Solubility: 1 mg/mL DMSO; 1 mg/mL water
Adisant LTD performed an HPLC analysis using a Thermo UltiMate 3000 HPLC System.
Niclosamide capsules should be kept at room temperature in their original package. The melting point fluctuates between 216 and 230 °C.
There are a few methods for determining the purity of niclosamide. Thin layer chromatography is a popular technique (TLC). TLC is a process that involves applying a sample on a plate that has been coated with a thin layer of adsorbent material. The plate is subsequently put in a solvent-containing development chamber. The sample will be carried up the plate by the solvent as it advances up the plate. Based on its solubility in the solvent, the sample will then divide into various components. When the plate is taken from the chamber, the various components emerge as distinct spots on the plate. The sample's purity is then measured by comparing the number of dots on the plate to a recognized standard.
High performance liquid chromatography is another approach for determining the purity of niclosamide (HPLC). TLC and HPLC are comparable, except the sample is introduced into the system under high pressure. This permits the material to be split into its constituents considerably quicker than TLC. The sample's purity may then be assessed by comparing the peak regions of the various components to a recognized standard.
Niclosamide capsules are a salicylanilides type of medication derivative. Niclosamide capsules should be kept at room temperature in their original package. Niclosamide pills must be consumed with meals. Nausea, vomiting, diarrhea, and stomach discomfort are common adverse effects. Contact your doctor if you suffer any of these negative effects.